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Dose adjustments based on renal function, age, and concomitant medications may be required.
Hazard ratios, 95% confidence intervals, and P values were calculated with the use of models adjusted for the following prespecified baseline prognostic factors: age, estimated GFR, ejection fraction, body-mass index, hemoglobin value, heart rate, systolic blood pressure, diabetes mellitus, history of hypertension, previous myocardial infarction, atrial fibrillation, and left bundle-branch block or QRS duration greater than 130 msec.
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Recent publications suggest improved outcomes when used for heart failure compared with furosemide.
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In 2 of 3 studies of patients with cirrhosis, torsemide increased natriuresis and total volume diuresed compared with furosemide in patients with cirrhosis; however, no significant difference between the agents with respect to plasma renin and aldosterone concentrations was demonstrated.
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Of the side effects listed in the table, only “excessive urination” occurred significantly more frequently in patients treated with torsemide than in patients treated with placebo.
Your medical professional might have also prescribed a potassium supplement for you.
Other antialdosterone and antifibrotic effects of torsemide are postulated, however, and warrant further study.
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The loop diuretic dose should be doubled until adequate diuresis occurs or until the maximum recommended dose is reached.
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Some other serious maladies that edema can indicate include congestive heart failure, cirrhosis, kidney disease or damage, chronic venous insufficiency, and inadequate lymphatic system.
Empagliflozin: May enhance the hypotensive effect of Loop Diuretics.
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Patients who have not responded to catecholamine therapy and patients with tachyarrhythmias are candidates for such treatment.
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To prevent hypokalemia and metabolic alkalosis, an aldosterone antagonist or potassium-sparing drug should be used concomitantly with DEMADEX.
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This disparity between the number of patients needing transplants and the availability of heart donors has refocused efforts to find other ways to support severely failing hearts.
We had no data on specific diuretics and their dosages, and more importantly, on patients' salt status and blood urea nitrogen levels.
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The results of an initial clinical trial suggested that treatment with the combination of a neprilysin inhibitor plus an experimental angiotensin receptor blocker (LCZ696) was superior to enalapril in reducing the risks of death and hospitalization for heart failure (McMurray et al, 2014).
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Diuretics (water pills): Diuretics, particularly furosemide ( Lasix), which belongs to a class called loop diuretics, may reduce levels of vitamin B1 in the body.
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Periodic determinations of other electrolytes are advised in patients treated with high doses or for prolonged periods, particularly in those on low-salt diets.
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